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General Practitioner Recruitment
General Practitioner Recruitment ME/CFS andLong COVID Myalgic Encephalomyeltis / Chronic Fatigue Syndrome (ME/CFS) is a multisystem, chronic and complex disease (msCCD) that, pre-COVID, affected around 230,000 Australians. In 2020, the direct medical cost was estimated at $5.295b, or $23,022 per case per year, and the aggregate community cost at $14.5b per year. Recent studies indicate […]
Biological Outlier and Subtyping
Software for Myalgic Encephalomyelitis
This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
Itaconate Trap Study
This project aims to look at metabolic traps in central carbon metabolism that lead to observed altered energy production pathways in ME/CFS.
Metabolic Differentiation of ME/CFS Comorbidities
To investigate the metabolite signatures of ME/CFS patient stool, urine and blood samples and the impact that co-morbidities (IBS and Fibromyalgia) have on these signatures.
Single Day Longitudinal Study
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
Deep Proteome and Metabolome Profiling
Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective.
Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through:
Deep phenotyping of ME patients
Global proteomic plasma profiling of ME patients
Global metabolomics plasma profiling of ME patients
Ocular Motor Study
Ocular Motor Study Study AIM The aim of this project is to fully characterise eye movement changes in ME/CFS on two consecutive days, identifying an ocular motor signature that is unique to the disorder. LEAD INVESTIGATORS Christopher Armstrong, PhD Joanne Fielding Meaghan Clough Updates and Potential Currently recruiting participants for this study. Preliminary trials on […]
Cellular Nitrogen and Energy Metabolism in ME/CFS
This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.
SPOT ME: Serial Pediatric Omics Tracking for ME/CFS
This study seeks to understand pathological mechanisms of pediatric ME/CFS (13 to 18 years old), using case-control and longitudinal study design that meshes clinical measures and omics methods.