Multi-Omic Approaches to Solve Post-Acute COVID-19 (MOSAIC)
The purpose of this study is to facilitate early detection of ME/CFS in people with Long COVID and better understand disease progression.
SIMPLE Study: Impact of Saline Infusion on ME/CFS, POTS and Long COVID
The study aims to compare the effectiveness of different saline formulations, including a placebo, in individuals with ME/CFS, Long COVID, and POTS, to determine the most beneficial types and understand their impact on patient improvement.
Neuroendocrine, Vascular and Metabolism in ME/CFS, POTS and Long COVID
The study aims to explore the structural, neuro-vascular, and biochemical differences in the brains of individuals with ME/CFS, Long COVID, and POTS to elucidate the underlying pathology and identify potential targets for effective treatment strategies.
Personalised Treatment Trials: Monitoring and Improving the Connection of Treatments to Patients
The study aims to deeply characterise patients before, during and after treatments are trialled through their GP. Producing large scale data in combination with treatment outcome will be used to produce a predictive algorithm to improve the connection of patients to appropriate treatment options sooner.
MELLOW: Tracking Hormonal Fluctuations in ME/CFS and Long COVID
The study aims to investigate how hormone fluctuations in individuals with ME/CFS and Long COVID, compared to healthy controls, impact metabolism and immune pathways by measuring hormones, metabolites, and inflammation markers in biofluid samples.
Blood Flow and Exercise in ME/CFS and Orthostatic Intolerance
The study aims to investigate the effects of supine vs upright exercise on cerebral blood flow, blood pressure, heart rate, and the presence of autoimmune antibodies in ME/CFS patients with orthostatic intolerance, compared to controls, to understand the underlying mechanisms and differences in symptom severity and post-exertional malaise.
25-Day Metabolite Monitoring Study of ME/CFS Patients
The study aims to meticulously analyse daily changes in metabolites from blood samples of individuals with ME/CFS over 25 days, to uncover the complex biological processes contributing to the condition and facilitate patient clustering by dynamic changes, thereby addressing the challenge of clinical and biological diversity within the ME/CFS population.
Crash-Course: Studying PEM/flares in ME/CFS, PTLDS, Long COVID
The study aims to compare biological markers during mild symptoms and flare/PEM events in individuals with ME/CFS, alongside PTLDS and Long COVID patients, using finger-prick blood samples and continuous data from wearable sensors to understand symptom variability.
AusME Biobank Biomarker Project
The study aims to utilise the Australian ME/CFS biobank for metabolomics analyses and other assays to identify potential biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, contributing to a comprehensive dataset for large-scale analysis.
BOSS-ME: Biological Outlier and
Subtyping Software for ME/CFS
This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
