Biological Outlier and Subtyping
Software for Myalgic Encephalomyelitis
This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
Itaconate Trap Study
This project aims to look at metabolic traps in central carbon metabolism that lead to observed altered energy production pathways in ME/CFS.
Metabolic Differentiation of ME/CFS Comorbidities
To investigate the metabolite signatures of ME/CFS patient stool, urine and blood samples and the impact that co-morbidities (IBS and Fibromyalgia) have on these signatures.
Single Day Longitudinal Study
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
Deep Proteome and Metabolome Profiling
Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective.
Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through:
Deep phenotyping of ME patients
Global proteomic plasma profiling of ME patients
Global metabolomics plasma profiling of ME patients
Cellular Nitrogen and Energy Metabolism in ME/CFS
This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.
SPOT ME: Serial Pediatric Omics Tracking for ME/CFS
This study seeks to understand pathological mechanisms of pediatric ME/CFS (13 to 18 years old), using case-control and longitudinal study design that meshes clinical measures and omics methods.
Characterizing B cells in ME/CFS
This study aims to broadly evaluate B cell subsets, metabolism, viability, receptors, and antibodies in people with ME/CFS.
Condensed precision research protocol for ME/CFS
Establish a condensed personalized research protocol that can be used to characterize ME/CFS in individual patients as it pertains to all their unique biological aspects of their self, interacting with a complex chronic disease.
Developing Rapid System for Outlier Analysis in ME/CFS
Establish an analytical workflow for outlier analysis in ME/CFS to identify disease or symptom exacerbators that may not be considered in the individual with ME/CFS (including gene mutations, elevated toxins) and then develop a software program to rapidly identify these potential anomalies.
